2）

湖南省自然科学基金青年项目，“食品成分与纳米颗粒的相互作用及其对纳米颗粒安全性的影响”，2018-2020，金额5万，主持

2）

Yingmei   Luo, Xuefeng Wang, Yi Cao*. Transcriptomic analysis suggested the   involvement of impaired lipid droplet biogenesis in graphene oxide-induced   cytotoxicity in human umbilical vein endothelial cells. Chemico-Biological   Interactions, 2021, 333:109325.

3）

Shuang Li, Xuejun Zheng, Chaobo Huang, Yi   Cao*. Titanate nanofibers reduce Kruppel-like factor 2 (KLF2)-eNOS   pathway in endothelial monolayer: a transcriptomic study. Chinese Chemical   Letters, 2021, 32:1569-1572.

4）

Yi Cao*, Shuang Li, Jiamao Chen. Modeling   better in vitro models for the prediction of nanoparticle toxicity: a review.   Toxicology Mechanisms and Methods, 2021, 31:1-17.

5）

Shuyi Wang, Jing Ma, Shuai Guo, Yuanyu Huang*, Yi Cao*.   Transcriptomic analysis revealed that multi-walled carbon nanotubes   diameter-dependently induced pyroptosis in THP-1 macrophages. NanoImpact,   2020, 20:100270.

6）

Ying Jiang#, Housheng   Gong#, Shaohua Jiang, Chaowen She*, Yi Cao*. Multi-walled carbon   nanotubes decrease neuronal NO synthase in 3D brain organoids. Science of the   Total Environment, 2020, 748:141384.

7）

Ting Yang#, Jiamao Chen#, Lingqiang Gao, Yuanyu Huang,   Guochao Liao*, Yi Cao*. Induction of lipid droplets in THP-1   macrophages by multi-walled carbon nanotubes in a diameter-dependent manner:   a transcriptomic study. Toxicology Letters, 2020, 332:65-73.

8）

Junkang Wang#, Jiaqi   Zhang#, Shuang Li, Chaobo Huang, Yixi Xie*, Yi Cao*. Anthocyanins   decrease the internalization of TiO2 nanoparticles into 3D Caco-2 spheroids.   Food Chemistry, 2020, 331:127360.

9）

Bihan Wu#, Mengdie   Jiang#, Xuewu Liu, Chaobo Huang, Zhipeng Gu*, Yi Cao*. Evaluation of toxicity   of halloysite nanotubes and multi-walled carbon nanotubes to endothelial   cells in vitro and blood vessels in vivo. Nanotoxicology, 2020, 14:1017-1038.

10）

Yingmei Luo, Jinfeng   Peng*, Chaobo Huang, Yi Cao*. Graphene oxide size-dependently altered   lipid profiles in THP-1 macrophages. Ecotoxicology and Environmental Safety,   2020, 199:110714

11）

Jinru Lin#, Ying Jiang#,   Yingmei Luo, Hao Guo, Chaobo Huang, Jinfeng Peng*, Yi Cao*.   Multi-walled carbon nanotubes (MWCNTs) transformed THP-1 macrophages into   foam cells: impact of pulmonary surfactant component   dipalmitoylphosphatidylcholine. Journal of Hazardous Materials, 2020,   392:122286.

12）

Shuang Li#, Hongji Liu#, Zhengzheng Zhou*, Yi Cao*.   Titanate nanotubes at non-cytotoxic concentrations affect NO signaling   pathway in human umbilical vein endothelial cells. Toxicology in Vitro, 2020,   62:104689.

13）

Yi Cao*, Yingmei Luo. Pharmacological and toxicological aspects of   carbon nanotubes (CNTs) to vascular system: a review. Toxicology and Applied   Pharmacology, 2019, 385:114801.

14）

Jing Li#, Haiyin Yang#, Suinan Sha, Jiaquan Li, Zhengzheng Zhou*,   Yi Cao*. Evaluation of in vitro toxicity of silica nanoparticles (NPs)   to lung cells: influence of cell types and pulmonary surfactant component   DPPC. Ecotoxicology and Environmental Safety, 2019, 186:109770.

15）

Xianqiang Li#, Yuanfang   Tang#, Chunying Chen, Dexin Qiu*, Yi Cao*. PEGylated gold nanorods are   not cytotoxic to human endothelial cells but affect kruppel-like factor   signaling pathway. Toxicology and Applied Pharmacology, 2019, 382:114758.

16）

Jimin Long, Wen Ma, Zhiqiang Yu, Hongwen Liu*, Yi Cao*.   Multi-walled carbon nanotubes (MWCNTs) promoted lipid accumulation in THP-1   macrophages through modulation of endoplasmic reticulum (ER) stress.   Nanotoxicology, 2019, 13:938-951.

17）

Haiyin Yang#, Jing Li#,   Chunguang Yang, Hongwen Liu*, Yi Cao*. Multi-walled carbon nanotubes   promoted lipid accumulation in human aortic smooth muscle cells. Toxicology   and Applied Pharmacology, 2019, 374:11-19.

18）

Qianyu Yang#, Maolin Wang#, Yongbing Sun, Shengming Peng, Yanhuai   Ding*, Yi Cao*. Pre-incubated with BSA-complexed free fatty acids   alters ER stress/autophagic gene expression by carboxylated multi-walled   carbon nanotube exposure in THP-1 macrophages. Chinese Chemical Letters,   2019, 30:1224-1228.

19）

Pantian Zhang, Pan She,   Jiahui He, Zexing Xiang, Zhaocheng Li, Yi Cao*, Xuefei Zhang*.   Full-biodegradable polylactide-based thermoresponsive copolymer with a wide   temperature range: Synthesis, characterization and thermoresponsive   properties. Reactive and Functional Polymers, 2019, 142:128-133.

20）

Leying Jiang#, Zhen Li#, Yixi Xie, Liangliang Liu*, Yi Cao*.   Cyanidin chloride modestly protects Caco-2 cells from ZnO nanoparticle   exposure probably through the induction of autophagy. Food and Chemical   Toxicology, 2019, 127: 251-259.

21）

Yongqi Liang#, Min Xie#,   Juan Li, Liangliang Liu*, Yi Cao*. Influence of 3-hydroxyflavone on   colloidal stability and internationalization of Ag nanomaterials. Dose   Response, 2019, 17 (3): 1559325819865713.

22）

Jiahui He, Wei Wang, Huicong Zhou, Pan She, Pantian Zhang, Yi   Cao*, XuefeiZhang*. A novel pH-sensitive polymeric prodrug was prepared   by SPAAC click chemistry for intracellular delivery of doxorubicin and   evaluation of its anti-cancer activity in vitro. Journal of Drug Devliery   Science and Technology, 2019, 53:101130.

23）

Xuqi Zhao#, Shiwei   Chang#, Jimin Long, Juan Li, Xianqiang Li*, Yi Cao*. The toxicity of   multi-walled carbon nanotubes (MWCNTs) to human endothelial cells: the   influence of diameters of MWCNTs. Food and Chemical Toxicology, 2019, 126:169-177.

24）

Ting Liu#, Hongying Liang#, Liangliang Liu, Yu Gong, Yanhuai   Ding, Guochao Liao*, Yi Cao*. Influence of pristine and hydrophobic   ZnO nanoparticles on cytotoxicity and endoplasmic reticulum (ER)   stress-autophagy-apoptosis gene expression in A549-macrophage co-culture.   Ecotoxicology and Environmental Safety, 2019, 167:188-195.

25）

Zhen Li#, Ting Liu#,   Jimin Long, Yang Wu, Biao Yan, Ping Ma*, Yi Cao*. The toxicity of   hydroxylated and carboxylated multi-walled carbon nanotubes to human   endothelial cells was not exacerbated by ER stress inducer. Chinese Chemical   Letters, 2019, 30:582-586.

26）

Jiamao Chen#, Ting Yang#, Jimin Long, Yanhuai Ding, Juan Li, Xianqiang   Li*, Yi Cao*. Palmitate enhanced the cytotoxicity of ZnO nanomaterials   possibly by promoting endoplasmic reticulum (ER) stress. Journal of Applied   Toxicology, 2019, 39:798-806.

27）

Dejian Yan#, Jimin   Long#, Jikai Liu*, Yi Cao*. The toxicity of ZnO nanomaterials to HepG2   cells: the influence of size and shape of particles. Journal of Applied Toxicology,   2019, 39:231-240.

28）

Yi Cao#, Ziyin Li#, Lianzhi Mao, Hehe Cao,   Jingjing Kong, BinYu, Changmin Yu*, Wenzhen Liao*. The use of proteomic   technologies to study molecular mechanisms of multidrug resistance in cancer.   European Journal of Medicinal Chemistry, 2019, 162:423-434.

29）

Mengdie Jiang#, Bihan   Wu#, Yongbing Sun, Yanhuai Ding, Yixi Xie, Liangliang Liu*, Yi Cao*.   Toxicity of ZnO nanoparticles (NPs) to THP-1 macrophages: interactions with   saturated or unsaturated free fatty acids. Toxicology Mechanisms and Methods,   2019, 29:291-299.

30）

Maolin Wang#, Qianyu Yang#, Jimin Long, Yanghuai Ding, Xiaoqing   Zou, Guochao Liao*, Yi Cao*. A comparative study of toxicity of TiO2,   ZnO and Ag nanoparticles to human aortic smooth muscle cells. International   Journal of Nanomedicine, 2018, 13:8037-8049.

31）

Chunxue Zhao#, Yiwei   Zhou#, Liangliang Liu, Jimin Long, Hongwen Liu, Juan Li*, Yi Cao*.   Lipid accumulation in multi-walled carbon nanotube-exposed HepG2 cells:   possible role of lipophagy pathway. Food and Chemical Toxicology, 2018,   121C:65-71.

32）

Shiwei Chang#, Xuqi Zhao#, Siyu Li, Tuqiang Liao, Jimin Long,   Zhiqiang Yu*, Yi Cao*. Cytotoxicity, cytokine release and ER stress-autophagy   gene expression in endothelial cells and alveolar-endothelial co-culture   exposed to pristine and carboxylated multi-walled carbon nanotubes.   Ecotoxicology and Environmental Safety, 2018, 161:569-577.

33）

Hongying Liang#, Tong   He#, Jimin Long, Liangliang Liu, Guochao Liao, Yanhuai Ding*, Yi Cao*.   Influence of bovine serum albumin pre-incubation on toxicity and ER   stress-apoptosis gene expression in THP-1 macrophages exposed to ZnO   nanoparticles. Toxicology Mechanisms and Methods, 2018, 28: 587-598.

34）

Yi Cao*, Yu Gong, Wenzhen Liao*, Yunfeng Luo,   Chaohua Wu, Maolin Wang, Qianyu Yang. A review of cardiovascular toxicity of   TiO2, ZnO and Ag nanoparticles (NPs). BioMetals, 2018, 31:457-476.

35）

Yunfeng Luo#, Chaohua   Wu#, Liangliang Liu, Yu Gong, Shengming Peng, Yixi Xie*, Yi Cao*.   3-Hydroxyflavone enhances the toxicity of ZnO nanoparticles (NPs) in vitro.   Journal of Applied Toxicology, 2018, 38:1206-1214.

36）

Cao Zhang#, Yining Li#, Liangliang   Liu, Yu Gong, Yixi Xie*, Yi Cao*. Chemical Structures of Polyphenols   That Critically Influence the Toxicity of ZnO Nanoparticles. Journal of   Agricultural and Food Chemistry, 2018, 66:1714-1722.

37）

Yining Li#, Cao Zhang#, Liangliang Liu,   Yu Gong, Yixi Xie*, Yi Cao*. The effects of baicalein or baicalin on   the colloidal stability of ZnO nanoparticles (NPs) and toxicity of NPs to   Caco-2 cells. Toxicology Mechanisms and Methods, 2018, 28:167-176.

38）

Yuexin   Shen#, Gui Chen#, Aiping Xiao, Yixi Xie, Liangliang Liu*, Yi Cao*. In   vitro effect of flaxseed oil and α-linolenic acid against the toxicity of   lipopolysaccharide (LPS) to human umbilical vein endothelial cells. Inflammopharmacology,   2018, 26:645-654.

39）

Wei Wang, Biyun Zhao, Xiangyang Meng, Pan   She, Pantian Zhang, Yi Cao*, Xuefei Zhang*. Preparation of dual-drug   conjugated polymeric micelles with synergistic anti-cancer efficacy in vitro.   Journal of Drug Delivery Science and Technology, 2018, 43:388-396.

40）

Jimin   Long, Yafang Xiao, Liangliang Liu*, Yi Cao*. The adverse vascular   effects of multi-walled carbon nanotubes (MWCNTs) to human vein endothelial   cells (HUVECs) in vitro: role of length of MWCNTs. Journal of Nanobiotechnology,   2017, 15:80.

41）

Tong He, Jimin Long, Juan Li, Liangliang   Liu*, Yi Cao*. Toxicity of ZnO nanoparticles (NPs) to A549 cells and   A549 epithelium in vitro: interactions with dipalmitoyl phosphatidylcholine   (DPPC). Environmental Toxicology and Pharmacology, 2017, 56:233-240.

42）

Xin   Fang#, Leying Jiang#, Yu Gong, Juan Li, Liangliang Liu*, Yi Cao*. The   presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the   toxicity of aged NPs to Caco-2 and HepG2 cells. Chemico-Biological Interactions,   2017, 278:40-47.

43）

Yu Gong, Liangliang Liu, Juan Li*, Yi   Cao*. The presence of palmitate affected the colloidal stability of ZnO   NPs but not the toxicity to Caco-2 cells. Journal of Nanoparticle Research,   2017, 19:335.

44）

Haikang Huang, Jing Yan , Pei Liu ,   Biyun Zhao , Yi Cao*, Xuefei Zhang*. A novel cancer nanotheranostics   system based on quantum dots encapsulated by polymer-prodrug with controlled   release behaviour. Australian Journal of Chemistry, 2017, 70:1302-1311.

45）

Yi   Cao*, Jimin Long, Liangliang Liu, Tong He,   Leying Jiang, Chunxue Zhao, Zhen Li. A review of endoplasmic reticulum (ER)   stress and nanoparticle (NP) exposure. Life Sciences, 2017, 186:33-42.

46）

Yiwei   Zhou#, Xin Fang#, Yu Gong, Aiping Xiao, Yixi Xie, Liangliang Liu*, Yi Cao*.   The Interactions between ZnO Nanoparticles (NPs) and α-Linolenic Acid (LNA)   Complexed to BSA Did Not Influence the Toxicity of ZnO NPs on HepG2 Cells.   Nanomaterials (Basel), 2017, 7(4): 91.

47）

Yi Cao*, Yu   Gong, Liangliang Liu, Yiwei Zhou, Xin Fang, Cao Zhang, Yining Li, Juan Li.   The use of human umbilical vein endothelial cells (HUVECs) as an in vitro   model to assess the toxicity of nanoparticles to endothelium: a review.   Journal of Applied Toxicology, 2017, 37:1359-1369.

48）

Yu   Gong, Yuejia Ji, Fang Liu, Juan Li*, Yi Cao*. Cytotoxicity, oxidative   stress and inflammation induced by ZnO nanoparticles in endothelial cells:   interaction with palmitate or lipopolysaccharide. Journal of Applied   Toxicology, 2017, 37: 895-901.

49）

Yi Cao*,   Yixi Xie*, Liangliang Liu, Aiping Xiao, Yining Li, Cao Zhang, Xin Fang, Yiwei   Zhou. Influence of phytochemicals on the biocompatibility of inorganic   nanoparticles: a state-of-the-art review. Phytochemistry Reviews, 2017, 16:   555-563.

50）

Yuxiu Gu#, Shanshan Cheng#, Gui Chen,   Yuexin Shen, Xiyue Li, Qin Jiang, Juan Li*, Yi Cao*. The effects of endoplasmic reticulum stress   inducer thapsigargin on the toxicity of ZnO or TiO2 nanoparticles to human   endothelial cells. Toxicology Mechanisms and Methods, 2017, 27: 191-200.

51）

Gui Chen#, Yuexin Shen#, Xiyue Li, Qin   Jiang, Shanshan Cheng, Yuxiu Gu, Liangliang Liu*, Yi Cao*. The endoplasmic reticulum stress inducer   thapsigargin enhances the toxicity of ZnO nanoparticles to macrophages and   macrophage-endothelial co-culture. Environmental Toxicology and Pharmacology,   2017, 50: 103-110.

52）

Fang Liu, Haikang Huang, Yu Gong, Juan   Li, Xuefei Zhang*, Yi Cao*. Evaluation of in vitro toxicity of polymeric   micelles to human endothelial cells under different conditions.   Chemico-Biological Interactions, 2017, 263:46-54.

53）

Qin Jiang#, Xiyue Li#, Shanshan Cheng,   Yuxiu Gu, Gui Chen, Yuexin Shen, Yixi Xie, Yi Cao*. Combined effects of low levels of palmitate on   toxicity of ZnO nanoparticles to THP-1 macrophages. Environmental Toxicology   and Pharmacology, 2016, 48:103-109.

54）

Yi Cao*, Jimin Long, Yuejia Ji, Gui Chen, Yuexin Shen, Yu   Gong , Juan Li. Foam cell formation by particulate matter (PM) exposure: a   review. Inhalation Toxicology, 2016, 28(13):583-590.

55）

Yi Cao*, Juan Li, Fang Liu, Xiyue Li, Qin Jiang, Shanshan   Cheng, Yuxiu Gu. Consideration of interaction between nanoparticles and food   components for the safety assessment of nanoparticles following oral   exposure: A review. Environmental Toxicology and Pharmacology, 2016,   46:206-210.

56）

Yi   Cao, Martin Roursgaard, Nicklas Raun   Jacobsen, Peter Møller, Steffen Loft. Monocyte adhesion induced by   multi-walled carbon nanotubes and palmitic acid in endothelial cells and   alveolar-endothelial co-cultures. Nanotoxicology, 2016, 10(2):235-244.

57）

Yi Cao*, Kim Jantzen, Ana Cecilia Damiao   Gouveia, Astrid Skovmand, Martin Roursgaard, Steffen Loft, Peter Møller.   Automobile diesel exhaust particles induce lipid droplet formation in   macrophages in vitro. Environmental Toxicology and Pharmacology, 2015,   56(2):97-110.

58）

Yi   Cao*, Dorthe A. Bindslev, Søren K.   Kjærgaard. Estimation of the in vitro eye irritating and inflammatory   potential of lipopolysaccharide (LPS) and dust by using reconstituted human   corneal epithelium tissue cultures. Toxicology Mechanisms and Methods, 2015,   25(5):402-409.

59）

Yi Cao*, Martin Roursgaard, Ali   Kermanizadeh, Steffen Loft, Peter Møller. Synergistic effects of zinc oxide   nanoparticle and fatty acid on toxicity to Caco-2 cells. International Journal   of Toxicology, 2015, 34(1):67-76.

60）

Yi   Cao, Martin Roursgaard, Pernille   Danielsen, Peter Møller, Steffen Loft. Carbon black nanoparticles promote   endothelial activation and lipid accumulation in macrophages independently of   intracellular ROS production. PLOS ONE, 2014, 9(9):e106711.

61）

Yi Cao, Nicklas Raun Jacobsen, Pernille   Danielsen, Anke G Lenz, Tobias Stoeger, Steffen Loft, Håkan Wallin, Martin   Roursgaard, Lone Mikkelsen, Peter Møller. Vascular effects of multi-walled   carbon nanotubes in dyslipidemic ApoE-/- mice and cultured endothelial cells.   Toxicological Sciences, 2014, 138(1):104-116.

62）

Yi   Cao, Sisi Liang, Yuduo Zheng, Dandan Liu,   Benyan Zhang, Dongqun Xu, Xu Yang. Induction of GSNO Reductase but not NOS in   glucan-Spiked Office Dust Exposed Mice Lungs. Environmental Toxicology, 2011,   26(3):279-86.

2）

Yi   Cao. Toxicity of Ingested Nanomaterials. In Food Toxicology: Current Advances   and Future Challenges. Editors: Ashish Sachan, Suzanne Hendrich. November,   2017 by Apple Academic Press.